GLP-1 medications have quickly become one of the most talked-about tools for weight loss — but what are they and what should you expect before starting?
If you’re considering GLP-1 treatment, here’s a clear, no-nonsense guide to how it works, what the experience feels like, and how to get the best results.
What Is GLP-1 and How Does It Work?
Glucagon-like peptide-1 (GLP-1), a naturally occurring hormone produced in the small intestine, helps the body manage incoming nutrients. This hormone helps regulate blood sugar, the speed of digestion, and appetite.
Naturally occurring GLP-1 is short-lived, quickly broken down by the DPP-4 enzyme. The medications semaglutide and tirzepatide are GLP-1 receptor agonists. They mimic the natural hormone but remain active in the bloodstream longer, producing more long-lasting effects. Tirzepatide also includes the hormone GIP, which enables greater control over cravings.
GLP-1 medications enhance the effects of naturally occurring GLP-1. They stimulate the pancreas to produce insulin when needed, slow the rate at which food leaves the stomach, and cross the blood–brain barrier to interact with the hypothalamus, decreasing the desire and cravings for food.
When combined with vitamin B6 or vitamin B12, and prescribed and managed by a licensed practitioner, GLP-1 treatment results in weight loss and improvements in weight-related health issues.
If you’ve been thinking about trying GLP-1 medications for your weight management journey, contact us today. You’ll speak with a caring nurse practitioner committed to helping you reach your goals.
What to Know When Starting Medications
The two leading GLP-1 medications on the market are semaglutide and tirzepatide. Both are taken as weekly injections that help regulate the metabolic system. Unlike stimulants, these medications provide effective benefits over time.
When starting semaglutide or tirzepatide, many patients notice a reduction in their desire and cravings for food within the first 24 to 48 hours. Weight changes typically start gradually and are noticeable in one to two months.
Side effects of GLP-1 medications include nausea, constipation, diarrhea, and fatigue. Such side effects usually last four to six weeks. Pairing GLP-1 medications with vitamin B6 or vitamin B12 can help reduce side effects. Contact us to speak to one of our licensed practitioners about which vitamin compound is best for you.
Understanding Your GLP-1 Dosing
GLP-1 treatments involve weekly injections prescribed by licensed practitioners. The medication is compounded by highly vetted and regulated pharmacies that meet quality and safety standards. As part of Skinny Clinic’s personalized concierge services, dosages will be fine-tuned based on regular meetings with your dedicated nurse practitioner.
Medication is sold in predefined quantities, but unlike prefilled GLP-1 pens, your prescription is customized. You’ll draw your weekly dose from a vial based on your provider’s instructions, with precise adjustments over time. Learn more about quantities and prescription pricing.
Because we tailor our prescriptions to the unique needs of each patient, it’s vital that patients understand the details of their prescription, especially for managing their dosages.
The graphic below breaks down the following prescription: 2 ml with 4 mg of 1 mg semaglutide/1 mg vitamin B12/0.5 ml. 2 ml is the total volume of medication the patient will receive. That 2 ml of medication contains 4 mg of semaglutide in a one-to-one ratio with vitamin B12, meaning every 0.5 ml of medication contains 1 mg each of semaglutide and vitamin B12. As such, one 2 ml vial can last as long as 10 weeks for some patients.
Dosing usually starts low and increases over time until patients find the amount of medication that achieves the desired results with minimal negative side effects.
Tips for Success
If you want to get the most out of your GLP-1 treatment and minimize the nausea, fatigue, and other side effects of medications, you’ll need to make a few lifestyle changes.
- Every bite counts. You’ll be eating smaller portions less often, so you need to make sure you’re getting enough nutrients when you do eat. To avoid muscle loss, monitor protein intake closely. TIP: Aim for 25 to 30 grams of protein per meal from lean meats, Greek yogurt, or high-quality protein shakes.
- Stay hydrated. It’s time to commit to your water bottle. Among the side effects of GLP-1s is a change in how your body signals thirst. So even if you’re not feeling thirsty, keep drinking water! TIP: Adding electrolytes to your water can help keep your energy up, especially during the first few weeks of medication.
- Manage digestion. What, when, and how much you eat matters. Large meals can cause gastric discomfort because GLP-1 medication slows digestion. TIP: Eat until you’re satisfied, not full.
Common Questions
What if I miss a dose?
Generally, you can take your missed dose within two days of your scheduled dose. If you miss this window, skip the dose and resume injections the following week. But be sure to confirm with your practitioner that this approach is right for you.
Will I be on this medication forever?
Individual health goals and metabolic history have a major impact on how long patients use GLP-1 medications for weight loss. While some patients will discontinue use after a short period, others will utilize medication as a tool for weight management long-term.
Can I eat whatever I want?
Although there aren’t any strictly prohibited foods while you’re taking GLP-1 medication, many patients find that foods high in fat and sugar cause more gastric upset.
How much weight can I expect to lose?
Many people lose 10%–20% of their body weight over time, depending on medication dosage and lifestyle. Healthy weight loss expectations should be discussed with your practitioner.
How fast does the medication work?
Most patients notice appetite changes relatively quickly, within a few weeks. Noticeable weight loss usually takes about one or two months. Expectations should be discussed with your licensed practitioner.
Do I need to diet and exercise while on GLP-1 treatment?
Typically, yes. Our patients get results more quickly and are able to maintain their weight loss when they implement lifestyle changes, such as increased activity and better food choices.
Can I drink alcohol on GLP-1?
Yes, but your tolerance may change, and nausea can worsen.
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